Episode 1

full
Published on:

15th Dec 2024

Exploring tTIS and Reinforcement Learning - #1 - Nov 7, 2024

Exploring Transcranial Temporal Interference Stimulation (tTIS) and Reinforcement Learning

In this episode of the Neurostimulation Podcast, hosted by Dr. Michael Passmore from the University of British Columbia, the focus is on Transcranial Temporal Interference Stimulation (TTIS) and its role in motor learning and reinforcement. The episode explores a study published in Nature Human Behavior which shows how TTIS can either enhance or disrupt motor learning by targeting the striatum, a critical brain region. Key insights include the methodology of using different frequencies of TTIS on healthy young adults, the impact on reinforcement learning, and the potential clinical applications for neurological conditions like Parkinson's disease. The discussion also delves into the ethical considerations and future directions for this promising non-invasive neurostimulation technology.

00:00 Welcome to the Neurostimulation Podcast

00:36 Introduction to Neurostimulation and Podcast Goals

01:43 Disclaimer and Personal Commitment

03:06 Today's Topic: Transcranial Temporal Interference Stimulation (TTIS)

04:14 Understanding TTIS: Mechanism and Bioengineering

06:37 Reinforcement Learning and the Striatum

10:04 The Study: Methodology and Experiment Design

13:46 Key Findings and Implications

16:50 Advanced Critical Appraisal of the Study

23:13 Future Directions and Ethical Considerations

26:37 Conclusion and Final Thoughts


Study:


Vassiliadis P, Beanato E, Popa T, Windel F, Morishita T, Neufeld E, et al. Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills. Nat Hum Behav. 2024;8(5):566–74. doi:10.1038/s41562-024-01901-z.


https://pubmed.ncbi.nlm.nih.gov/38811696/


tTIS resources:


Transcranial Temporal Interference Stimulation (tTIS) is an emerging non-invasive neuromodulation technique designed to target deep brain regions with precision.


• TI Solutions: This company specializes in developing devices and planning tools for temporal interference research. Their website offers detailed information on the science behind tTIS, device descriptions, and recent advancements in the field. 


https://temporalinterference.com


• Brainbox: Brainbox provides an overview of temporal interference, including its principles, applications, and associated products. The site also references key studies and offers insights into the technique’s potential. 


https://brainbox-neuro.com/techniques/temporal-interference


• Frontiers in Human Neuroscience: This journal features articles such as “A mini-review: recent advancements in temporal interference stimulation in modulating brain function and behavior,” which discusses the latest research and findings related to tTIS. 


https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2023.1266753/full


• EPFL News: The École Polytechnique Fédérale de Lausanne (EPFL) has published articles on non-invasive deep brain stimulation techniques, including tTIS, and their applications in enhancing motor learning. 


https://actu.epfl.ch/news/non-invasive-deep-brain-stimulation-enhances-motor

Next Episode All Episodes Previous Episode

Listen for free

Show artwork for The Neurostimulation Podcast

About the Podcast

The Neurostimulation Podcast
Exploring the frontier of interventional mental health.
Welcome to The Neurostimulation Podcast — a deep dive into the expanding frontier of interventional mental health.

Hosted by Dr. Michael Passmore, a psychiatrist specializing in neurostimulation and geriatric mental health, this show explores how cutting-edge interventions — from non-invasive brain stimulation (TMS, tDCS, and beyond) to ketamine-assisted psychotherapy — are reshaping the landscape of modern psychiatry and neuroscience.

Each episode bridges science, clinical experience, and human insight, featuring thought leaders and innovators who are redefining how we understand and treat the mind.

Whether you’re a clinician, researcher, student, or simply fascinated by the brain, you’ll discover practical knowledge, fresh ideas, and inspiring conversations that illuminate the evolving art and science of mental health care.

Subscribe for episodes that stimulate your mind, deepen your understanding, and connect you to the future of brain-based healing.

podscan_YIPb4jA8fBJ5ino2RSuBo3BdjrOmPM6c

About your host

Profile picture for Michael Passmore

Michael Passmore

Dr. Michael Passmore is a psychiatrist based in Vancouver, BC, with expertise in non-invasive neurostimulation therapies, geriatric mental health and ketamine-assisted psychotherapy. Having completed specialized training in multiple neurostimulation modalities, including electroconvulsive therapy at Duke University and transcranial magnetic stimulation at Harvard University, Dr. Passmore brings a robust clinical and academic background to his practice. Formerly the head of the neurostimulation program in the department of Psychiatry at Providence Health Care, Dr. Passmore now serves as a clinical associate professor at the University of British Columbia’s Department of Psychiatry. At Sea to Sky NeuroClinic (seatoskyneuro.clinic), Dr. Passmore offers interventional mental health treatments tailored to clients across Canada.​